House of the Dead 3 takes you on a thrilling action-adventure of cinematic proportions full of spectacular surprises and emotional encounters. In each stage, the player will fight against different types of vile creatures and a boss character. The boss character will appear at different timings in each stage. Sometimes it will appear at the beginning, sometimes during the middle of the stage, and sometimes at the end. A new feature of this game is that the player can choose which stage they want to challenge next. This allows the players to use their own strategy in the game. However, even in the same stage, the events will change depending on the sequence of stages that the player took to get there. This will ensure that the player will experience something new each time.